1. Romans 3:23
"for all have sinned and fall short of the glory of God,"
This foundational verse in Paul's systematic theology establishes the universal nature of human depravity. The Greek "hamartano" (ἁμαρτάνω) literally means "to miss the mark," derived from archery where an arrow falls short of its target. R.C. Sproul notes this reveals sin's essence: humanity's failure to achieve God's perfect standard of righteousness. The aorist tense indicates a completed action with ongoing consequences - all have sinned and continue to fall short. John MacArthur emphasizes this doctrine of total depravity, showing that sin affects every aspect of human nature, making divine grace absolutely necessary for salvation. (Ligonier Ministries)